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Scientists set to boost gene delivery with $500m plant project

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GLOBAL leader in gene delivery solutions, VectorBuilder Inc.  has announced the construction of a new R&D and manufacturing center in Guangzhou, China.

  This was made known by the Chief Scientist at VectorBuilder, Dr. Bruce Lahn while announcing the company’s capacity  to research  and develop  reliable gene delivery vectors.

  “ Modern biology is largely built on gene delivery technologies, but until recently, such technologies are mostly limited to research use. With the recent advancement of genetic medicine, gene vectors are now rapidly moving into clinical use, including CAR-T, gene therapy, mRNA vaccines and oncolytic viruses. Some experts predict that in 10 to 20 years, vector-based drugs will become the third pillar of medicine, after small-molecule drugs and protein-based biologics. We are therefore expanding our R&D capabilities, as well as our manufacturing capacity, to continue leading the way in the development of innovative gene delivery technologies that will make research more efficient, and genetic medicine more effective and affordable.” Lahn stated.

  According to the Scientist, the ‘Gene Delivery Research and Manufacturing Campus’ will significantly expand VectorBuilder’s R&D capabilities and its production capacity for both research-use and cGMP-grade gene delivery vectors, allowing the company to continue supporting groundbreaking research worldwide.

   He emphasised that  the campus will include a state-of-the-art CDMO facility with 30 production suites, designed for cGMP manufacturing of plasmids, mRNA, AAV, lentivirus, cell lines, and other types of viral and non-viral vectors. It will also offer CRO services for vector optimisation and functional validation, and non-GLP and GLP studies for vector biodistribution, ADME/PK/PD, and toxicology.

  “Additionally, the campus will be home to a research institute dedicated to developing new gene delivery technologies that improve upon current tools in terms of targeting efficiency, payload, safety, and manufacturing cost, to meet the demand in clinical applications such as gene therapy, vector-based vaccines, and virus-based cancer therapeutics. The research institute will also carry out educational activities aimed at training scientists and engineers in the rapidly expanding gene delivery field. Construction is expected to cost 500 million USD and will be split into two phases over the next four years.” The scientist stated.

  Meanwhile, VectorBuilder has assured there will be “approximately 100,000 m2 (~1,100,000 sf) of floor space capable of housing over 2,000 staff members. This project is part of a global expansion by VectorBuilder, with additional R&D and manufacturing sites planned in the US, Europe and Japan.” 

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